Learn about our world class antibodies for a diverse set of research areas including immunology, neuroscience, cancer, stem cells and cell biology.
Work with our experienced scientific team and leverage our advanced technologies to help accelerate the preclinical drug discovery process.
Work with our experienced scientific team and leverage our advanced technologies to help accelerate the preclinical drug discovery process.
Work with our experienced scientific team and leverage our advanced technologies to help accelerate the preclinical drug discovery process.
Work with our experienced scientific team and leverage our advanced technologies to help accelerate the preclinical drug discovery process.
Work with our experienced scientific team and leverage our advanced technologies to help accelerate the preclinical drug discovery process.
Work with our experienced scientific team and leverage our advanced technologies to help accelerate the preclinical drug discovery process.
Work with our experienced scientific team and leverage our advanced technologies to help accelerate the preclinical drug discovery process.
Work with our experienced scientific team and leverage our advanced technologies to help accelerate the preclinical drug discovery process.
Work with our experienced scientific team and leverage our advanced technologies to help accelerate the preclinical drug discovery process.
Revvity's Oxford Diagnostic Laboratories is a large referral laboratory for tuberculosis testing services based on our T-SPOT technology.
Revvity's Oxford Diagnostic Laboratories is a large referral laboratory for tuberculosis testing services based on our T-SPOT technology.
Revvity's Oxford Diagnostic Laboratories is a large referral laboratory for tuberculosis testing services based on our T-SPOT technology.
Revvity's Oxford Diagnostic Laboratories is a large referral laboratory for tuberculosis testing services based on our T-SPOT technology.
Revvity's Oxford Diagnostic Laboratories is a large referral laboratory for tuberculosis testing services based on our T-SPOT technology.
Revvity's Oxford Diagnostic Laboratories is a large referral laboratory for tuberculosis testing services based on our T-SPOT technology.
Revvity's Oxford Diagnostic Laboratories is a large referral laboratory for tuberculosis testing services based on our T-SPOT technology.
Revvity's Oxford Diagnostic Laboratories is a large referral laboratory for tuberculosis testing services based on our T-SPOT technology.
Revvity's Oxford Diagnostic Laboratories is a large referral laboratory for tuberculosis testing services based on our T-SPOT technology.
Revvity's Oxford Diagnostic Laboratories is a large referral laboratory for tuberculosis testing services based on our T-SPOT technology.
Revvity's Oxford Diagnostic Laboratories is a large referral laboratory for tuberculosis testing services based on our T-SPOT technology.
Revvity's Oxford Diagnostic Laboratories is a large referral laboratory for tuberculosis testing services based on our T-SPOT technology.
Revvity's Oxford Diagnostic Laboratories is a large referral laboratory for tuberculosis testing services based on our T-SPOT technology.
Revvity's expression platform provides an enhanced system for the development and manufacturing of biotherapeutics that can be used in commercial manufacturing applications.
Revvity's expression platform provides an enhanced system for the development and manufacturing of biotherapeutics that can be used in commercial manufacturing applications.
Revvity's expression platform provides an enhanced system for the development and manufacturing of biotherapeutics that can be used in commercial manufacturing applications.
Revvity's expression platform provides an enhanced system for the development and manufacturing of biotherapeutics that can be used in commercial manufacturing applications.
Revvity's expression platform provides an enhanced system for the development and manufacturing of biotherapeutics that can be used in commercial manufacturing applications.
Revvity's Oxford Diagnostic Laboratories is a large referral laboratory for tuberculosis testing services based on our T-SPOT technology.
Revvity's Oxford Diagnostic Laboratories is a large referral laboratory for tuberculosis testing services based on our T-SPOT technology.
Revvity's Oxford Diagnostic Laboratories is a large referral laboratory for tuberculosis testing services based on our T-SPOT technology.
Revvity's Oxford Diagnostic Laboratories is a large referral laboratory for tuberculosis testing services based on our T-SPOT technology.
Revvity's Oxford Diagnostic Laboratories is a large referral laboratory for tuberculosis testing services based on our T-SPOT technology.
Revvity's Oxford Diagnostic Laboratories is a large referral laboratory for tuberculosis testing services based on our T-SPOT technology.
Revvity's Oxford Diagnostic Laboratories is a large referral laboratory for tuberculosis testing services based on our T-SPOT technology.
Revvity's Oxford Diagnostic Laboratories is a large referral laboratory for tuberculosis testing services based on our T-SPOT technology.
Revvity's Oxford Diagnostic Laboratories is a large referral laboratory for tuberculosis testing services based on our T-SPOT technology.
Revvity's Oxford Diagnostic Laboratories is a large referral laboratory for tuberculosis testing services based on our T-SPOT technology.
Revvity's Oxford Diagnostic Laboratories is a large referral laboratory for tuberculosis testing services based on our T-SPOT technology.
Revvity's Oxford Diagnostic Laboratories is a large referral laboratory for tuberculosis testing services based on our T-SPOT technology.
Driving meaningful innovation that profoundly impacts science and human lives.
Driving meaningful innovation that profoundly impacts science and human lives.
Driving meaningful innovation that profoundly impacts science and human lives.
Driving meaningful innovation that profoundly impacts science and human lives.
Quickly find and download manuals, safety documents, certificates of analysis and more.
Quickly find and download manuals, safety documents, certificates of analysis and more.
Quickly find and download manuals, safety documents, certificates of analysis and more.
Quickly find and download manuals, safety documents, certificates of analysis and more.
Quickly find and download manuals, safety documents, certificates of analysis and more.
Quickly find and download manuals, safety documents, certificates of analysis and more.
Quickly find and download manuals, safety documents, certificates of analysis and more.
Quickly find and download manuals, safety documents, certificates of analysis and more.
Quickly find and download manuals, safety documents, certificates of analysis and more.
Quickly find and download manuals, safety documents, certificates of analysis and more.
Quickly find and download manuals, safety documents, certificates of analysis and more.
Quickly find and download manuals, safety documents, certificates of analysis and more.
Quickly find and download manuals, safety documents, certificates of analysis and more.
Quickly find and download manuals, safety documents, certificates of analysis and more.
Quickly find and download manuals, safety documents, certificates of analysis and more.
Quickly find and download manuals, safety documents, certificates of analysis and more.
Quickly find and download manuals, safety documents, certificates of analysis and more.
Quickly find and download manuals, safety documents, certificates of analysis and more.
Quickly find and download manuals, safety documents, certificates of analysis and more.
Quickly find and download manuals, safety documents, certificates of analysis and more.
Quickly find and download manuals, safety documents, certificates of analysis and more.
Quickly find and download manuals, safety documents, certificates of analysis and more.
Quickly find and download manuals, safety documents, certificates of analysis and more.
Quickly find and download manuals, safety documents, certificates of analysis and more.
Quickly find and download manuals, safety documents, certificates of analysis and more.
Quickly find and download manuals, safety documents, certificates of analysis and more.
Quickly find and download manuals, safety documents, certificates of analysis and more.
Quickly find and download manuals, safety documents, certificates of analysis and more.
Quickly find and download manuals, safety documents, certificates of analysis and more.
Quickly find and download manuals, safety documents, certificates of analysis and more.
Quickly find and download manuals, safety documents, certificates of analysis and more.
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KRAS is a proto-oncogene known to be mutated in many cancer subtypes, inducing uncontrolled proliferation and cell metabolism changes. Like most small GTPases, KRAS will bind to GDP in its inactive form or to GTP in its active form. KRAS G12C is one of the most commonly found mutant forms in cancers, and leads to a permanently active state of KRAS. The upregulation of KRAS interaction with the exchange factor SOS1 leads to cancer phenotypes. Reducing KRAS activity and associated pathways could control the biological processes involved in cancer growth. Furthermore, it is well known that KRAS induces activation of mitogen-activated protein kinase (MAPK), thus playing a central role in human cancers.
This application note provides a convincing demonstration of the reliability of the AlphaLISA and HTRF KRAS portfolios to evaluate compound in vitro therapeutic profiles in a cellular context:
For research use only. Not for use in diagnostic procedures.
Detection of MAPK activation to evaluate the efficacy and potency of KRAS/SOS1 inhibitors by AlphaLISA and HTRF technologies