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Literature - Publication Review
The future of immunotherapy gets brighter with base editing
This literature review discusses how base editing technology addresses the shortcomings of other gene editing technologies for immunotherapy.
Whitepaper
Base editing and stem-cell based therapies
This white paper explores how base editing is advancing iPSCs in the fields of basic science, regenerative medicine and immunotherapy.
Whitepaper
Addressing the challenges in solid tumor therapy with base editing
Read this white paper to learn about how base editing is helping to address key challenges in immunotherapies for solid tumors.
Scientific Poster
A single-step process for engineering hypoimmunogenic pluripotent stem cells with the Pin-point™ platform
Learn about the utility of the Pin-point™ base editing platform for the engineering of allogeneic PSCs.
Scientific Poster
Interchanging Cas enzymes, deaminases, and aptamerguide RNA combinations to achieve optimal editing with the modular Pin-point™ base editing platform
Learn how to apply multiplex base editing to efficiently develop engineered CAR-T cells and hypoimmunogenic iPSCs.
Application Note
Base editing with nuclease flexibility
In this application note, we demonstrate how the Pin-point™ base editing platform’s modularity allows for its components to be optimized to the target site.
Brochure
The Pin-point™ platform: A novel modular base editing system
This presentation provides an overview of the Pin-point base editing platform by describing its key benefits, how it works, and supporting data.
Whitepaper
CRISPR-derived base editing technology: The what, the how, and the why
This white paper provides a comprehensive guide to base editing, including what it is, how it works and applications.
Scientific Poster
One-step generation of allogeneic CAR-T cells by simultaneous multiplex knockout and site-specific transgene integration with the Pin-point™ base editing platform
Discover one-step generation of allogeneic CAR-T cells by simultaneous multiplex knockout and site-specific transgene integration with the Pin-point™ base editing platform.
Scientific Poster
Achieving CAR-T cell generation in a single intervention using a multiplex base editing system
In this poster, we highlight an example configuration of the Pin-point technology for the streamlined generation of allogeneic CAR-T cells and hypoimmunogenic iPSCs.
Application Note
Increasing the targeting scope and precision of next-generation gene editing technology
In this application note, we demonstrate the Pin-point™ base editing system as a novel nucleaseagnostic modular platform for increasing the targeting scope and precision of next-generation gene editing technology.
Scientific Poster
Development and validation of customized guide RNA design and efficiency prediction tools for the Pin-point base editing platform
This scientific poster describes the development and validation of customized guide RNA design and efficiency prediction tools for the Pin-point base editing platform.
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