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Article
Busting high-content imaging myths
High-content imaging has become a cornerstone of life science research, providing valuable insights into cellular function and drug responses. However, as with any advanced technology, misconceptions and myths can emerge. In this article, we’ll debunk some of the most common myths surrounding high-content imaging, shedding light on its true strengths and limitations.
Technical Note
3D volumetric and zonal analysis of solid spheroids
Technical note describing how to image and analyze solid spheroids in 3D.
Application Note
Label-free analysis of cardiomyocyte beating using the Opera Phenix Plus System
Learn how to reliable quantify cardiomyocyte beating frequency using the Opera Phenix Plus high-content screening system in this application note.
Technical Note
Clearing strategies for 3D spheroids
In this technical note, we compare optical clearing strategies for 3D spheroids and demonstrate how to increase imaging depth in 3D spheroids by a factor of 4.
Application Note
Phenotypic analysis of CRISPR-Cas9 cell-cycle knockouts using cell painting
Learn about our harmonized workflow for morphological profiling of CRISPR-Cas9-mediated knockouts using cell painting in this Application Note.
Application Note
Kinetic analysis of calcium flux activity in human iPSC-derived neurons using the Opera Phenix Plus system
Application note for fast kinetic imaging using HCS to visualize and evaluate spontaneous calcium flux activity in single human iPSC-derived neurons
Guide
Harness the power of 3D cell model imaging
In our guide, learn how to harness the power of 3D cell model imaging.
Technical Note
How to perform long term live cell imaging in a high‑content analysis system
Technical note describing How to Perform Successful Long-Term Live-Cell Imaging in a High-Content Analysis or Screening System
Technical Note
Opera Phenix High-Content Screening System: Improved 3D imaging
Technical Note describing how imaging of 3D cell models is improved using the Opera Phenix High-Content Screening System
Application Note
Phenotypic profiling of autophagy using high content profiler
Using an autophagy assay as an example, this study describes the validation of a phenotypic image and data analysis workflow.
Case Study
Improving the throughput of a neuroprotection assay using the opera phenix high content screening system
Download the case study to learn how primary neuron morphology is analyzed in a straightforward approach using Harmony® software and careful assay optimization can increase throughput, and minimize the data burden, without compromising assay performance.
Case Study
Re-tooling anti-microbial research for the 21st century
Case study describing the analysis of bacterial phenotypes to investigate adaptive mechanisms of antimicrobial resistance and screening for novel alternatives.
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