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Application Note
Effectiveness of CRISPR-Cas9 using pools of Dharmacon™ Edit-R™ synthetic crRNAs in high-content analysis screening experiments
Find out about the effectiveness of CRISPR-Cas9 using pools of Dharmacon™ Edit-R™ synthetic crRNAs in HCA screening experiments.
Application Note
Pooled phenotypic CRISPR screening enables the identification of synergistic drug combinations for cancer therapy
This application note demonstrates how a pooled phenotypic CRISPR screening can be used to identify synergistic drug combinations for cancer therapy
Application Note
CRISPRsc: Pooled CRISPR screening with single-cell transcriptome resolution
This application note describes a pooled CRISPR screen with single-cell transcriptome resolution to link gene expression signature with drug response.
Application Note
CRISPR-Cas9 screening for target identification
Explore the power of whole-genome CRISPR-Cas9 screening in this application note.
Application Note
CRISPRa: Transcriptional upregulation screening with genome-wide CRISPR activation
This application note demonstrates transcriptional upregulation screening with genome-wide CRISPR activation.
Application Note
The dual screen: Parallel genome-wide CRISPRi and CRISPRa screening
Discover the advantages of a dual screen using CRISPRi and CRISPRa screening in parallel in this application note.
Application Note
CRISPRi: Transcriptional repression screening with genome-wide CRISPR interference
This application note demonstrates transcriptional regression screening with a novel whole-genome CRISPRi platform.
Application Note
Target essentiality assay
This application note demonstrates Revvity’s target essentiality assay which indicates whether or not a specific gene is essential for survival and/or proliferation in a given cell line.
Application Note
2D OncoSignature™ Long-Term Assay: Extending the reach of cell panel screens
This application note describes the development of the 2D OncoSignature™ Long-Term Assay (LTA) drug discovery service.
Application Note
Development of a near infrared fluorescent labeled agent for assessing bombesin receptor expression in cancer
This application note highlights using IVISense Bombesin Receptor fluorescent probe to assess bombesin receptor expression in cancer
Application Note
Advancing autophagy detection: HTRF LC3B-II assay for specific and reliable LC3B-II detection
This study validates the HTRF LC3B-II immunoassay as a reliable, precise, and faster alternative to the traditional LC3 Western Blot for quantifying autophagy in various cellular models.
Application Note
Modulation of Bcl-2 Expression in MCF7 Cells Using LANCE TR-FRET Technology
This study demonstrates the effectiveness of LANCE Ultra TR-FRET assay technology in identifying and characterizing Bcl-2 protein expression in MCF7 cells, with expression levels modulated by agents that induce cell death and affect proliferation. The assay’s versatility is further highlighted by its application to suspension cell lines and frozen cellular lysates.
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