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Application Note
Pharmacological validation of a panel of GPCRs with the HTRF GTP Gi Binding Assay
This application note discusses the characterization process for candidate molecules targeting Gα-protein activation through GPCRs with the functional HTRF GTP binding assay.
Application Note
Download your protocol on CD4 T cells differentiation into Th17 cells
In this application note is reported a protocol for the isolation of mouse naïve CD4+ T-cells and their differentiation into T-Reg and Th-17 cells.
Application Note
TotalSeq™ and DepleteX® technologies for efficient analysis of the cellular transcriptome
Read this app note to explore the compatibility of TotalSeq™ and DepleteX® kits in 10x Genomics workflows for efficient analysis of the cellular transcriptome.
Application Note
Automated RNA purification from PAXgene Tubes with chemagic 360 instrument
Discover automated high-quality RNA isolation from PAXgene Blood RNA Tubes using chemagic 360. Stable storage, efficient extraction, and RT-PCR compatibility for transcriptome analysis.
Application Note
Comparison of automated nucleic acid purification systems HMW DNA extraction efficiency
Read this app note to compare automated nucleic acid purification systems for high-quality DNA/RNA extraction. Evaluate yield, purity, and HMW DNA integrity for NGS, long-read sequencing, and MLPA applications.
Application Note
Rapid screening of novel therapeutics by ImmuSignature™ T cell activation assay
This application note describes the development of a robust T cell activation assay to assess the impact of novel therapeutics on T cell function.
Application Note
Base editing with nuclease flexibility
In this application note, we demonstrate how the Pin-point™ base editing platform’s modularity allows for its components to be optimized to the target site.
Application Note
Optimization of complement-dependent cytotoxicity assay on OncoSignature cell lines
This application note provides insight into how our complement-dependent cytotoxicity assay can help drug screening efforts by leveraging our semi-automated screening platform and OncoSignature™ cell panel.
Application Note
2D OncoSignature™ Long-Term Assay: Extending the reach of cell panel screens
This application note describes the development of the 2D OncoSignature™ Long-Term Assay (LTA) drug discovery service.
Application Note
Effectiveness of CRISPR-Cas9 using pools of Dharmacon™ Edit-R™ synthetic crRNAs in high-content analysis screening experiments
Find out about the effectiveness of CRISPR-Cas9 using pools of Dharmacon™ Edit-R™ synthetic crRNAs in HCA screening experiments.
Application Note
Pooled phenotypic CRISPR screening enables the identification of synergistic drug combinations for cancer therapy
This application note demonstrates how a pooled phenotypic CRISPR screening can be used to identify synergistic drug combinations for cancer therapy
Application Note
CRISPRsc: Pooled CRISPR screening with single-cell transcriptome resolution
This application note describes a pooled CRISPR screen with single-cell transcriptome resolution to link gene expression signature with drug response.
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