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Literature - Publication Review
Ultrasound imaging provides noninvasive 3D views into vascular changes in response to cancer therapy
Ultrasound imaging using the Vega® automated system provides noninvasive 3D views into vascular changes in response to cancer therapy.
Literature - Publication Review
Expert interview: recapitulating the blood-brain barrier using in vitro hiPSC models in drug discovery
Better understand the blood-brain barrier for translational research and drug discovery in neurodegenerative diseases.
Literature - Publication Review
The impact of pan-KRAS inhibitors on cancer drug discovery
Read how Boehringer Ingelheim generated compounds to target the "undruggable" KRAS pathway with the help of Revvity's preclinical services.
Literature - Publication Review
SVEP1 as a regulator of GPCR-mediated vasoconstriction
This literature review describes how scientists uncovered multifunctional roles of SVEP1, a known contributor to cardiovascular disease.
Literature - Publication Review
Inhibiting interleukin 11 signaling reduces and reverses many dangerous effects of NAFLD/NASH in mouse models
Study demonstrating that inhibiting Interleukin 11 Signaling Reduces Hepatocyte Death and Liver Fibrosis, Inflammation, and Steatosis in Mouse Models of NASH
Literature - Publication Review
Clinically translatable cytokine delivery platform for eradication of intraperitoneal tumors
Researchers use a clinically translatable cytokine delivery platform in an ovarian mouse model validated using IVIS® optical imaging and IVISbrite™ D-luciferin bioluminescent substrate.
Literature - Publication Review
DNA origami elevates the design of multispecific antibodies as cancer therapeutic agents
Publication review highlighting the use of the IVIS™ Lumina X5 optical imaging system and BioLegend Antibodies describe programmable T cell engagers (PTEs), a novel class of agents created with DNA origami, a nanotechnology that allows the precise spatial arrangement of biomolecules. When combined with antibodies, this approach holds great promise to develop specific and effective biomedical nanotherapies for diseases like cancer.
Literature - Publication Review
Exploring mechanisms behind alphavirus-induced post-encephalitic parkinsonism
neuroinvasive viruses eliciting neurodegenerative symptoms of post-encephalitic parkinsonism by using bioluminescent or fluorescent recombinant WEEV in an in vivo mouse model
Literature - Publication Review
Evaluating a novel nanoparticle platform for controlled liraglutide release in a Type II diabetes mouse model
Optical imaging using the IVIS® Platform to evaluate a novel nanoparticle system for controlled liraglutide release in a diabetic mouse model.
Literature - Publication Review
Improving engineered T cell efficacy for treating solid tumors through epigenetic modulation
Researchers used the Opera Phenix® HCS and IVIS® preclicinal imaging system to evaluate engineered T-cells through epigenetic modulation showing the potential of improving the cytotoxic effects on solid tumors.
Literature - Publication Review
In vivo imaging of influenza virus infection in immunized mice
Using the IVIS® in vivo imaging platform to quantifiy H1N1pmd09-Nluc influenza viral load in mice and demonstrated that human mAb administration has a protective or therapeutic effect in mice challenged with influenza virus.
Literature - Publication Review
Biopolymers Codelivering Engineered T Cells and STING Agonists can Eliminate Heterogenous Tumors
Using the IVIS® Spectrum non-invasive preclinical optical system to quantify tumor-specific T cells responses in NFAT-luciferase transgenic mice.
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