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Deciphering the role of neutrophils in virus-induced respiratory disease
Preclinical imaging of neutrophilic response in viral infection with IVISense™ Neutrophil Elastase fluorescent probes.
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Meet the scientist: uncovering the pathways dictating evolution of lung cancer heterogeneity
Understanding why tumors evolve from a single cell to a heterogenous tissue could direct the development of new therapies.
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Murine NASH model could provide insights into NASH development and progression
Researchers explore a multidisciplinary approach to addressing current NAFLD and NASH challenges.
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Generating a clonal HAP1LIG4(-) Cas9(+) cell line – an expert interview
An interview with Dr. Gerety, the Sanger Institute on generating a new HAP1 cell line and how it can help advance scientific discovery.
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The importance of combination therapy for modern cancer treatments
This white paper discusses the importance of combination therapy for modern cancer treatments.
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Genetically engineered PDX models as patient avatars in preclinical evaluation of acute leukemias
Identifying therapeutic targets using gene silencing techniques in PDX models
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Bioluminescence Resonance Energy Transfer (BRET) to monitor protein-protein interactions
The ability to image PPIs in vivo has important implications for a wide variety of biological research endeavors, including drug discovery and molecular medicine.
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Non-invasive optical imaging for viral research and novel therapeutic and vaccine development
Non-invasive optical image using IVIS ® systems for pre-clinical viral research.
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Accelerating immuno-oncology therapeutic development: choosing the best preclinical model
Selecting the appropriate preclinical model for immuno-oncology therapeutic development.
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Eyes on synaptotagmin 7 (SYT7) in synaptic function and neuroplastic health for cognitive decline
Researcher, Dr. Jason Vevea, describes the role of synaptotogmin 7 in the synaptic vesicle cycle and the experimental steps taken to discover that SYT7 supports asynchronous release, short-term synaptic plasticity, and synaptic vesicle replenishment.
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Research spotlight: new therapeutic targets focusing on aberrant lipid metabolism in Alzheimer’s disease
This whitepaper explores new therapeutic targets focusing on Aberrant Lipid Metabolism in Alzheimer's Disease
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Antibody-based therapeutic modalities in oncology
Explore monoclonal antibody-based cancer therapeutics in this white paper, covering mechanism of action, development, and challenges.
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