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High content screening in three dimensions
This paper provides a recommended workflow for 3D HCS analysis, with a focus on reducing the 3D image analysis time by utilizing High Performance Computing.
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Spotlight research interview: narcolepsy, a neurological autoimmune disorder
Researchers were first to demonstrate direct evidence of autoreactive immune cells in narcolepsy patients, providing evidence of autoimmune basis
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An emerging therapeutic modality - RNA carves its path out of the paradigm
Learn more about several promising classes of RNA therapeutic, including RNAi, CRISPR, base editing, and mRNA vaccines, as well as the potential to combine RNA technologies with CAR-T.
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Lentiviral high-throughput assay shows promise for identifying novel HIV-1 inhibitors
Lentiviral high-throughput assay shows promise for identifying novel HIV-1 inhibitors
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Targeting leishmaniasis with an entamoeba molecule
An immune-therapeutic approach to leishmaniasis treatment by targeting leishmaniasis with an entamoeba molecule.
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Gene editing of primary immune cells to aid next-generation cellular immunotherapies
Researchers have successfully deployed CRISPRa/i in primary human T cells, offering critical insights into the pathways required for cytokine regulation.
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Assessing juvenile batten disease on Brain Development in In Vitro 3D organoid models
Assessing Juvenile Neuronal ceroid lipofuscinosis (JNCL) on brain development in Vitro 3D organoid Models.
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High-Throughput Approaches to Overcome Antimicrobial Resistance - Part 2
The use of machine learning algorithms to predict how an organism is going to behave in response to an antimicrobial.
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COVID-19 therapeutics: demand, challenges, and the future
Whitepaper provides insights into why developing effective COVID-19 treatments plays a significant role in pandemic control and explores therapeutic approaches pursued.
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Postbiotics: a paradigm shift in microbiome research
Investigating the impact of molecules produced by microbiota metabolism, known as postbiotics, on the human host
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A brand-new modality on the horizon: how targeted protein degradation can address the unmet need in drug discovery and development
Discover the potential of Targeted Protein Degradation (TPD) as an emerging drug discovery modality. Explore how TPD enables the selective targeting and degradation of proteins, even those previously considered "undruggable."
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Ex Vivo Functional Drug Testing of 3D Patient-Derived Cancer Cells Shows Promise for Personalized Medicine
Demonstrating how functional testing of 3D patient-derived cancer cells enables effective drug sensitivity testing.
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