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Application Note
No-Wash IP1 assays are a powerful readout to characterize compounds modulating the FGFR signaling pathway in cancer drug research
This application note demonstrates that detecting the intracellular accumulation of IP1, mediated by FGFR-dependent activation of PLCγ1, can be a powerful alternative for characterizing compounds that modulate FGFR signaling in various cancer cell lines expressing FGFR1, FGFR2, and FGFR3.
Technical Note
Nuclei segmentation on brightfield images using a pre-trained Artificial Intelligence (AI) model
Technical note describing the use of Phenologic.AI software module, for Signals Image Artist and Harmony image analysis software, for nuclei segmentation of brightfield images.
Technical Note
High-content imaging of brain-on-chip microfluidic devices using PreciScan intelligent acquisition.
In collaboration with ETAP-Lab, this technical note demonstrates automated image acquisition of brain-on-chip microfluidic devices for neuronal research.
Literature - Publication Review
Advanced characterization tools for organoid research: Analyzing cell type diversity, morphology, and function
Literature review highlighting advancements in organoid characterization techniques for analyzing cell type diversity, morphology, and function.
Article
Revolutionizing neurodegenerative disease research with brain-on-chip technology
The potential transformative impact of brain-on-chip technology on the field of neuroscience.
Application Note
Evaluation of drug selectivity and efficacy using PROTACs in a 3D co-culture spheroid model
The aim of this study was to evaluate the efficacy and selectivity of SJF1528, a pan-EGFR PROTAC, and MS39, a mutant-specific EGFR L858R PROTAC, while exploring the use of both high-content imaging and no-wash HTRF immunoassays in encapsulated 3D spheroid models.
Application Note
Characterizing chemokine receptor inhibitors with AlphaLISA SureFire Ultra, Alpha SureFire Ultra Multiplex and LANCE Ultra cAMP assays
This application note demonstrates how the SureFire Ultra and LANCE Ultra cAMP assays can be used for measuring inhibitors to CCR7 and CXCR2 cell surface receptors using a cellular model system where these receptors are overexpressed in CHO cells.
Whitepaper
Targeted protein degradation: A novel therapeutic strategy for neurodegenerative diseases
In this white paper, get details about TPD that offers a novel strategy for neurodegenerative diseases by degrading disease-linked proteins, showing promise in preclinical studies.
Whitepaper
Shifting the treatment paradigm: the promise of gene therapy for neurodegenerative diseases
Traditional treatments for neurodegenerative diseases focus on managing symptoms, but recent advancements in gene therapy offer hope for more effective and sustainable solutions. Read now!
Flyer
Better tools for better biology. ViaStain Reagents for the Celigo Image Cytometer
Flyer describing ViaStain reagents, dyes and kits for cell-based assays on the Celigo Image Cytometer, including viability, apoptosis and proliferation.
Application Note
A novel method for T-cell immunophenotyping using the Cellometer Spectrum image cytometer.
Application note describing a novel method for T-cell immunophenotyping using the Cellometer Spectrum image cytometer.
Flyer
Cellometer Spectrum image cytometer flyer
Flyer summarizing the Cellometer Spectrum image cytometer.
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