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Case Study
A workflow to characterize and benchmark human induced pluripotent stem cells
Case study describing a high-content imaging workflow to characterize and benchmark human induced pluripotent stem cells
Literature - Publication Review
Artemisinins target GABAA receptor signaling and impair α cell identity
Artemisinins Target GABA Receptor Signaling and Impair α Cell Identity encouraging α cells to convert into insulin-producing β-like cells.
Whitepaper
Spotlight research interview: narcolepsy, a neurological autoimmune disorder
Researchers were first to demonstrate direct evidence of autoreactive immune cells in narcolepsy patients, providing evidence of autoimmune basis
Literature - Publication Review
Bone morphogenetic protein 8B - a promising therapeutic avenue for NASH treatment
Bone Morphogenetic Protein 8B investigated as a Promising Therapeutic Avenue for NASH Treatment
Literature - Publication Review
hESC-derived cardiomyocyte screening platform identifies novel inhibitors of SARS-Cov-2 viral entry
Understand the pathology of SARS-CoV-2 in cardiomyocytes with a screening platform using human embryonic stem cell dervied cardiomyocytes (hESC-CMs)
Literature - Publication Review
Utility of engineered human Neural Stem Cells (NSCs) expressing varying exon 1 HTT fragments to study Huntington’s disease
Huntington's disease is most commonly caused by an expansion mutation in the CAG trinucleotide repeat within exon 1 of the HTT gene which codes for the protein huntingtin.
Literature - Publication Review
Prolonging ß cell proliferation with a 3D culture system
Disque Platform technology for evaluating drug candidates to treat ß cell loss in patients with diabetes.
Whitepaper
Lentiviral high-throughput assay shows promise for identifying novel HIV-1 inhibitors
Lentiviral high-throughput assay shows promise for identifying novel HIV-1 inhibitors
Literature - Publication Review
The modulatory effects of A2AR on NMDAR functionality using primary neurons and microglia cultures for potential neuroprotection in Alzheimer’s disease
Neurodegenerative Diseases Therapies; CNS Research, A2AR, Alzheimer's Disease, NMDAR, Acetylcholinesterase inhibitors
Application Note
Measuring FRET using the Opera™ Phenix™ high-content screening system
Here, we present a FRET-based high-content screening assay to study the interaction of the anti-apoptotic protein Bcl-XL with the pro-apoptotic protein Bad.
Application Note
A multiparametric live-cell cytotoxicity analysis using the Operetta High-content Analysis System
An in vitro cytotoxicity approach using HepG2 cells, which are used as an effective indicator of the human hepatotoxicity potential of test compounds.
Application Note
Imaging bile canaliculi in 3D liver microtissues
Here, we describe a 3D HCS assay to study hepatobiliary transporter function in InSphero human liver microtissues using the Opera Phenix™ HCS system.
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