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Guide Icon   Guide
AlphaLISA SureFire Ultra: the ultimate guide for successful experiments
The definitive guide for setting up a successful AlphaLISA SureFire Ultra assay. Several biological processes are regulated by protein phosphorylation.
Application Note Icon   Application Note
Using IP1 assays to study FGFR mediated pathways for cancer drug research
Detection of IP1 accumulation was achieved using either a no wash Revvity HTRF or AlphaLISA kits. These assays enable the rapid and accurate measurement of the activation status of intracellular downstream key enzymes and second messengers
Whitepaper Icon   Whitepaper
Epigenetic modifications and how they relate to cancer development and therapy
In this white paper, you’ll learn the general description of the three types of epigenetic modifications, how they play diverse roles in tumorigenesis and cancer progression, and the promising future of epigenetics in cancer.
Whitepaper Icon   Whitepaper
An overview of atherosclerosis
Recent developments in our understanding of atherosclerosis from a molecular perspective include the discovery of new players in disease pathogenesis. Discover more in this white paper!
Technical Note Icon   Technical Note
How to access true Kd values in Protein-Protein Interaction assays
This technical note draws on different case scenarios and assay formats to demonstrate the usefulness of the Cheng Prusoff equation in predicting PPI inhibitors potency.
Technical Note Icon   Technical Note
Best practices for analyzing brain samples with HTRF
This technical note will ensure that you obtain accurate results that you can interpret correctly.
Application Note Icon   Application Note
Antigen-stimulated PBMC cytokine release measured by AlphaLISA bovine cytokine kits
This application note demonstrates the performance of AlphaLISA bovine cytokine kits by measuring the cytokine release from antigenstimulated PBMCs isolated from cow blood and shows how cytokine measurements are critical for understanding cell mediated immune responses during vaccine development.
Application Note Icon   Application Note
A fast and simple chemiluminescent assay for monitoring of DNA-protein interactions
In this application note, we use HepG2 nuclear extracts to demonstrate the binding of Sp1 and HNF1 transcription factors to tagged oligonucleotides containing required cognate response elements. Read this note to see the results and access detailed data compared to EMSA.
Application Note Icon   Application Note
Protocol optimization for detection and quantification of membrane-bound proteins using AlphaLISA technology
AlphaLISA kits have the capability to assess hundreds of targets, including cytokines, proteins circulating in the blood, and cellular proteins.
Application Note Icon   Application Note
No-Wash IP1 assays are a powerful readout to characterize compounds modulating the FGFR signaling pathway in cancer drug research
This application note demonstrates that detecting the intracellular accumulation of IP1, mediated by FGFR-dependent activation of PLCγ1, can be a powerful alternative for characterizing compounds that modulate FGFR signaling in various cancer cell lines expressing FGFR1, FGFR2, and FGFR3.
Application Note Icon   Application Note
Characterizing chemokine receptor inhibitors with AlphaLISA SureFire Ultra, Alpha SureFire Ultra Multiplex and LANCE Ultra cAMP assays
This application note demonstrates how the SureFire Ultra and LANCE Ultra cAMP assays can be used for measuring inhibitors to CCR7 and CXCR2 cell surface receptors using a cellular model system where these receptors are overexpressed in CHO cells.
Flyer Icon   Flyer
Reagent solutions for autoimmunity research
Combat autoimmune diseases efficiently with our reagent technologies. Explore a broad biochemical portfolio targeting inflammation pathways.
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